3.0
Summary
| Name |  PRKRA
|
| Full Name | Interferon-inducible double-stranded RNA-dependent protein kinase activator A |
| Synonyms | PKR-associated protein X, PKR-associating protein X, Protein activator of the interferon-induced protein kinase, Protein kinase, interferon-inducible double-stranded RNA-dependent activator | PACT, RAX |
| Primary ID | O75569 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKRA | form complex 
binding
|
DICER1/hAgo2/PRKRA | 0.758 |
| Publications: | 1 | Organism: | Homo Sapiens | |