Relation Results

Summary

Name MTA2
Full Name Metastasis-associated protein MTA2
Synonyms Metastasis-associated 1-like 1, MTA1-L1 protein, p53 target protein in deacetylase complex | MTA1L1, PID
Primary ID O94776
Links - -
Type protein
Relations 4
Function May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone p ...
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Type: Score: Layout: SPV 
0.8210.20.8180.249MTA2MBD3/NuRD complexTBX5MBD2/NuRD complexFSHR

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Relations
Regulator
Mechanism
target
score ℹ
+ MTA2form complex img/form-complex.png binding MBD3/NuRD complex 0.821
Identifier Residue Sequence Organism Cell Line
SIGNOR-263853 Homo sapiens
pmid sentence
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. This complex is important for early development and for the stability and repair of our genes. Three proteins make up its core: HDAC1, which removes the acetyl group from the nucleosome; MTA1, which acts as a scaffold to hold the complex together; and RBBP4, which enables the complex to interact with nucleosomes. MBD2 and MBD3 are members of the methyl cytosine-guanosine (CpG)-binding domain (MBD) family of proteins42; 43. Of the five MBD members, only MBD2 and MBD3 associate with NuRD and are required for the complex formation and gene repression.
Publications: 1 Organism: Homo Sapiens
+ TBX5down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MTA2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255256 Homo sapiens
pmid sentence
TBX5 suppressed tumor cell proliferation and metastasis through the upregulation of cyclin-dependent kinase inhibitor 2A, metastasis suppressor 1 and downregulation of synuclein gamma and metastasis-associated protein 1 family member 2.
Publications: 1 Organism: Homo Sapiens
+ MTA2form complex img/form-complex.png binding MBD2/NuRD complex 0.818
Identifier Residue Sequence Organism Cell Line
SIGNOR-263841 Homo sapiens
pmid sentence
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. This complex is important for early development and for the stability and repair of our genes. Three proteins make up its core: HDAC1, which removes the acetyl group from the nucleosome; MTA1, which acts as a scaffold to hold the complex together; and RBBP4, which enables the complex to interact with nucleosomes. MBD2 and MBD3 are members of the methyl cytosine-guanosine (CpG)-binding domain (MBD) family of proteins42; 43. Of the five MBD members, only MBD2 and MBD3 associate with NuRD and are required for the complex formation and gene repression.
Publications: 1 Organism: Homo Sapiens
+ MTA2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FSHR 0.249
Identifier Residue Sequence Organism Cell Line
SIGNOR-254226 Homo sapiens Sertoli Cell
pmid sentence
Chromatin modifier MTA2 participates in the down-regulation of FSHR transcription. MTA2 is a potent corepressor of FSHR transcription, because it can recruit histone deacetylase-1 onto the FSHR promoter and participates in the down-regulation of FSHR expression upon FSH treatment.
Publications: 1 Organism: Homo Sapiens
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