Summary

Name ERLIN2
Full Name Erlin-2
Synonyms Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2 | C8orf2, SPFH2
Primary ID O94905
Links - -
Type protein
Relations 1
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).

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Relations

Regulator Mechanism target score ℹ
+ ERLIN2form complex img/form-complex.png binding Erlin 0.626
Publications: 1 Organism: Rattus Fuscipes