| + |
PRKCA |
phosphorylation
|
IL2RA |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-22984 |
Ser268 |
WQRRQRKsRRTI |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 2303462 |
The interleukin-2 (il-2) receptor, the leukocyte-specific membrane glycoprotein, t200, and the class i major histocompatibility antigens (hla) have been identified as substrates for protein kinase c from these studies, it was concluded that ser-247 is the major site of phosphorylation in the il-2 receptor and that thr-250 is a minor site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-22988 |
Thr271 |
RQRKSRRtI |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 2303462 |
The interleukin-2 (il-2) receptor, the leukocyte-specific membrane glycoprotein, t200, and the class i major histocompatibility antigens (hla) have been identified as substrates for protein kinase c from these studies, it was concluded that ser-247 is the major site of phosphorylation in the il-2 receptor and that thr-250 is a minor site. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
denileukin diftitox | up-regulates activity 
chemical activation
|
IL2RA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259392 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15757436 |
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELF1 | up-regulates quantity by expression 
transcriptional regulation
|
IL2RA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240193 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 7862168 |
The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated. Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
125-L-serine-2-133-interleukin 2 (human reduced) | up-regulates activity
chemical activation
|
IL2RA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18031103 |
Aldesleukin (recombinant IL-2) has similar pharmacodynamic properties to endogenous IL-2 and, when administered to patients with cancer, stimulates the antitumour immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGB1 | up-regulates quantity by expression
transcriptional regulation
|
IL2RA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240113 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 7862168 |
The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated. Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
IL2RA |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80336 |
|
|
Homo sapiens |
Thymoma Cell |
| pmid |
sentence |
| 10933396 |
Activation of notch1 signaling in dp thymocytes and thymoma cell lines results in the upregulation of cd25 and cd44 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | up-regulates
binding
|
IL2RA |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL2RA
- 
- 