Relation Results

Summary

Name NTRK1
Full Name High affinity nerve growth factor receptor
Synonyms Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA | MTC, TRK, TRKA
Primary ID P04629
Links - -
Type protein
Relations 28
Inhibitors LSM-1231; anthra[1,9-cd]pyrazol-6(2H)-one; regorafenib
Function Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferat ...
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Type: Score: Layout: SPV 
0.7720.20.4840.3820.80.5920.530.6930.2780.80.5230.5370.8390.6430.9550.3760.480.7730.8NTRK1SHC3PTPN6PTPN1LSM-1231ARHGAP32SH2B1NTF4CBLBanthra[1,9-cd]pyrazol-6(2H)-oneABL1SH2B2SHC1PLCG1NGFDUSP26RAB7AFRS2regorafenib

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ NTRK1up-regulates activity img/direct-activation.png phosphorylation SHC3 (isoform 2) 0.772
Identifier Residue Sequence Organism Cell Line
SIGNOR-273913 Tyr218 GDGSDHPyYNSIPSK in vitro
pmid sentence
We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosphopeptide mapping analysis using GST-fused N-Shc protein, and found that N-Shc phosphorylated by TrkA in vitro was resolved into at least seven phosphopeptides (Y1 through Y7, Figure 4a). Phosphopeptide mapping revealed that N-Shc has novel tyrosine-phosphorylation sites at Y259/Y260 and Y286; in vivo-phosphorylation of these tyrosines was demonstrated by site-specific anti-pTyr antibodies. Phosphorylated Y286 bound to several proteins, of which one was Crk. The pY221/pY222 site, corresponding to one of the Grb2-binding sites of Shc, also preferentially bound to Crk. The phosphorylation-dependent interaction between N-Shc and Crk was demonstrated in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273915 Tyr219 DGSDHPYyNSIPSKM in vitro
pmid sentence
We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosphopeptide mapping analysis using GST-fused N-Shc protein, and found that N-Shc phosphorylated by TrkA in vitro was resolved into at least seven phosphopeptides (Y1 through Y7, Figure 4a). Phosphopeptide mapping revealed that N-Shc has novel tyrosine-phosphorylation sites at Y259/Y260 and Y286; in vivo-phosphorylation of these tyrosines was demonstrated by site-specific anti-pTyr antibodies. Phosphorylated Y286 bound to several proteins, of which one was Crk. The pY221/pY222 site, corresponding to one of the Grb2-binding sites of Shc, also preferentially bound to Crk. The phosphorylation-dependent interaction between N-Shc and Crk was demonstrated in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273914 Tyr283 RQGSSDIySTPEGKL in vitro
pmid sentence
We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosphopeptide mapping analysis using GST-fused N-Shc protein, and found that N-Shc phosphorylated by TrkA in vitro was resolved into at least seven phosphopeptides (Y1 through Y7, Figure 4a). Phosphopeptide mapping revealed that N-Shc has novel tyrosine-phosphorylation sites at Y259/Y260 and Y286; in vivo-phosphorylation of these tyrosines was demonstrated by site-specific anti-pTyr antibodies. Phosphorylated Y286 bound to several proteins, of which one was Crk. The pY221/pY222 site, corresponding to one of the Grb2-binding sites of Shc, also preferentially bound to Crk. The phosphorylation-dependent interaction between N-Shc and Crk was demonstrated in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273923 Tyr301 PTGEAPTyVNTQQIP in vitro
pmid sentence
We also obtained tryptic phosphopeptide maps of N-Shc protein phosphorylated in vitro by other tyrosine kinases, TrkB, v-Src and EGFR. The overall patterns of the phosphopeptide maps generated by these tyrosine kinases were similar, although there were some differences among these maps (Figure 4a–d).We performed phosphopeptide mapping analysis using GST-fused N-Shc protein, and found that N-Shc phosphorylated by TrkA in vitro was resolved into at least seven phosphopeptides (Y1 through Y7, Figure 4a). Phosphopeptide mapping revealed that N-Shc has novel tyrosine-phosphorylation sites at Y259/Y260 and Y286; in vivo-phosphorylation of these tyrosines was demonstrated by site-specific anti-pTyr antibodies. Phosphorylated Y286 bound to several proteins, of which one was Crk. The pY221/pY222 site, corresponding to one of the Grb2-binding sites of Shc, also preferentially bound to Crk. The phosphorylation-dependent interaction between N-Shc and Crk was demonstrated in vitro and in vivo.
Publications: 4 Organism: In Vitro
+ NTRK1up-regulates img/direct-activation.png phosphorylation NTRK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-47167 Tyr496 HIIENPQyFSDACVH Homo sapiens
pmid sentence
In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785
Identifier Residue Sequence Organism Cell Line
SIGNOR-47171 Tyr676 FGMSRDIySTDYYRV Homo sapiens
pmid sentence
In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785
Identifier Residue Sequence Organism Cell Line
SIGNOR-47175 Tyr680 RDIYSTDyYRVGGRT Homo sapiens
pmid sentence
In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785
Identifier Residue Sequence Organism Cell Line
SIGNOR-47179 Tyr681 DIYSTDYyRVGGRTM Homo sapiens
pmid sentence
In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785
Identifier Residue Sequence Organism Cell Line
SIGNOR-47183 Tyr791 LAQAPPVyLDVLG Homo sapiens
pmid sentence
In vitro studies indicate that trka autophosphorylates at tyrosines 490, 670, 674, 675, and 785
Publications: 5 Organism: Homo Sapiens
+ PTPN6down-regulates activity img/direct_inhibition.png dephosphorylation NTRK1 0.484
Identifier Residue Sequence Organism Cell Line
SIGNOR-248468 Tyr680 RDIYSTDyYRVGGRT Rattus norvegicus
pmid sentence
Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated it at Y674/675.
Identifier Residue Sequence Organism Cell Line
SIGNOR-248469 Tyr681 DIYSTDYyRVGGRTM Rattus norvegicus
pmid sentence
Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated it at Y674/675.
Publications: 2 Organism: Rattus Norvegicus
+ PTPN1down-regulates activity img/direct_inhibition.png dephosphorylation NTRK1 0.382
Identifier Residue Sequence Organism Cell Line
SIGNOR-277081 Homo sapiens
pmid sentence
PTP1B inactivation prevents TrkA exit from soma and causes receptor degradation, suggesting a " gate-keeper " mechanism that ensures targeting of inactive receptors to axons to engage with ligand.|We identify a gate keeping mechanism in which TrkA receptors, destined for transcytosis, are dephosphorylated in neuronal soma by the ER-resident tyrosine phosphatase, PTP1B.
Publications: 1 Organism: Homo Sapiens
+ LSM-1231down-regulates activity img/direct_inhibition.png chemical inhibition NTRK1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258238 in vitro
pmid sentence
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here.
Publications: 1 Organism: In Vitro
+ NTRK1up-regulates img/direct-activation.png relocalization ARHGAP32 0.592
Identifier Residue Sequence Organism Cell Line
SIGNOR-95809 Homo sapiens
pmid sentence
Grit translocation was regulated by receptor stimulation
Publications: 1 Organism: Homo Sapiens
+ NTRK1up-regulates img/direct-activation.png binding SH2B1 0.53
Identifier Residue Sequence Organism Cell Line
SIGNOR-124198 Homo sapiens Neuron
pmid sentence
The adapter protein sh2-b has been shown to bind to activated nerve growth factor (ngf) receptor trka and has been implicated in ngf-induced neuronal differentiation and the survival of sympathetic neurons.
Publications: 1 Organism: Homo Sapiens
+ NTF4up-regulates img/direct-activation.png binding NTRK1 0.693
Identifier Residue Sequence Organism Cell Line
SIGNOR-85117 Homo sapiens
pmid sentence
Ngf is the preferred ligand for trka, bdnf and nt4/5 are preferred for trkb, and nt3 for trkc (barbacid 1994). These specificities are not absolute, and nt3 is also a ligand for trka and trkb.
Publications: 1 Organism: Homo Sapiens
+ CBLBdown-regulates quantity img/direct_inhibition.png ubiquitination NTRK1 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-278690 Homo sapiens
pmid sentence
Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.|Viral expression of constitutively active Cbl-b in DRGs of osteoarthritic mice effectively repressed TrkA protein level and more importantly, alleviated mechanical allodynia and heat hyperalgesia.
Publications: 1 Organism: Homo Sapiens
+ anthra[1,9-cd]pyrazol-6(2H)-onedown-regulates img/direct_inhibition.png chemical inhibition NTRK1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-170617 Homo sapiens
pmid sentence
In comparison, in the same assay conditions, the previously reported mps1 inhibitor sp600125 (13) was 10-fold less potent than nms-p715 on mps1 and, in addition, it was highly unspecific, being more active on at least 12 kinases including mitotic kinases.
Publications: 1 Organism: Homo Sapiens
+ NTRK1up-regulates img/direct-activation.png binding ABL1 0.523
Identifier Residue Sequence Organism Cell Line
SIGNOR-75402 Homo sapiens
pmid sentence
Autophosphorylated trka binds directly to plc?, Abl, and shc.
Publications: 1 Organism: Homo Sapiens
+ NTRK1up-regulates img/direct-activation.png phosphorylation SH2B2 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-62619 Homo sapiens Neuron
pmid sentence
Two substrates of trk kinases, raps and sh2-b. raps and sh2-b mediate trk signaling in developing neurons
Publications: 1 Organism: Homo Sapiens
+ NTRK1up-regulates img/direct-activation.png binding SHC1 0.839
Identifier Residue Sequence Organism Cell Line
SIGNOR-75408 Homo sapiens Neuron
pmid sentence
Autophosphorylated trka binds directly to plc?, Abl, and shc.
Publications: 1 Organism: Homo Sapiens
+ NTRK1up-regulates img/direct-activation.png phosphorylation, binding PLCG1 0.643
Identifier Residue Sequence Organism Cell Line
SIGNOR-38538 Homo sapiens
pmid sentence
The nerve growth factor (ngf) receptor/trk associated with and phosphorylated phospholipase c gamma (plc gamma)
Identifier Residue Sequence Organism Cell Line
SIGNOR-75405 Homo sapiens Neuron
pmid sentence
Autophosphorylated trka binds directly to plc?, Abl, and shc.
Publications: 2 Organism: Homo Sapiens
+ NGFup-regulates img/direct-activation.png binding NTRK1 0.955
Identifier Residue Sequence Organism Cell Line
SIGNOR-85114 Homo sapiens
pmid sentence
Ngf is the preferred ligand for trka, bdnf and nt4/5 are preferred for trkb, and nt3 for trkc (barbacid 1994). These specificities are not absolute, and nt3 is also a ligand for trka and trkb.
Publications: 1 Organism: Homo Sapiens
+ DUSP26down-regulates activity img/direct_inhibition.png dephosphorylation NTRK1 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-277105 Homo sapiens
pmid sentence
NEAP and DUSP26 dephosphorylated TrkA and FGFR1 directly.|We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF) receptor TrkA and fibroblast growth factor receptor 1 (FGFR1) activation in PC12 cells
Publications: 1 Organism: Homo Sapiens
+ RAB7Adown-regulates activity img/direct_inhibition.png binding NTRK1 0.48
Identifier Residue Sequence Organism Cell Line
SIGNOR-261305 Rattus norvegicus
pmid sentence
Endogenous TrkA and Rab7 form a complex. Inhibition of Rab7 potentiates the signaling of TrkA in response to brief stimulations with NGF
Publications: 1 Organism: Rattus Norvegicus
+ NTRK1up-regulates img/direct-activation.png binding FRS2 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-65955 Homo sapiens
pmid sentence
The signaling adapter frs-2 competes with shc for binding to the nerve growth factor receptor trka:a model for discriminating proliferation and differentiation
Publications: 1 Organism: Homo Sapiens
+ regorafenibdown-regulates activity img/direct_inhibition.png chemical inhibition NTRK1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259212 Homo sapiens
pmid sentence
In biochemical in vitro or cell-based assays, Regorafenib or its major human active metabolites M-2 and M-5 inhibited the activity of RET,VEGFR 1-3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2, DDR2, TrkA, Eph2A, RAF-1, BRAF, BRAFV600E, SAPK2, PTK5, and Abl at concentrations that can be achieved clinically.
Publications: 1 Organism: Homo Sapiens
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