Summary

Name RPN1
Full Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Synonyms Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1
Primary ID P04843
Links - -
Type protein
Relations 4
Function Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding OPRM1 0.256
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding OST-A complex 0.795
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding OST-B complex 0.785
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RPN1 0.368
Publications: 1 Organism: Homo Sapiens