Summary

Name CYP2E1
Full Name Cytochrome P450 2E1
Synonyms 4-nitrophenol 2-hydroxylase, 1.14.13.n7, CYPIIE1, Cytochrome P450-J | CYP2E
Primary ID P05181
Links - -
Type protein
Relations 2
Function A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png CYP2E1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CYP2E1 0.2
Publications: 1 Organism: Homo Sapiens