| + |
CHD8 | down-regulates quantity 
transcriptional regulation
|
NEFM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268917 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NEFM | form complex 
binding
|
Neurofilament L/M |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255271 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19468066 |
Neurofilaments are obligate heteropolymers that are minimally comprised of the low molecular neurofilament protein L (NFL) plus the medium and/or high molecular weight proteins neurofilament protein M (NFM) and neurofilament protein H |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEFM | up-regulates 
|
Neurofilament bundle assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8376466 |
Neurofilaments (NFs), composed of three distinct subunits NF-L, NF-M, and NF-H, are neuron-specific intermediate filaments present in most mature neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NEFM
- 
- 