+ |
ABL1 | up-regulates activity
phosphorylation
|
GPX1 |
0.472 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-104324 |
Tyr98 |
EILNSLKyVRPGGGF |
Homo sapiens |
|
pmid |
sentence |
12893824 |
GPx1 also functions as a substrate for c-Abl- and Arg-mediated phosphorylation on Tyr-96. The results further show that c-Abl and Arg stimulate GPx activity and that these kinases contribute to GPx-mediated protection of cells against oxidative stress. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ABL2 | up-regulates activity
phosphorylation
|
GPX1 |
0.327 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-104328 |
Tyr98 |
EILNSLKyVRPGGGF |
Homo sapiens |
|
pmid |
sentence |
12893824 |
GPx1 also functions as a substrate for c-Abl- and Arg-mediated phosphorylation on Tyr-96. The results further show that c-Abl and Arg stimulate GPx activity and that these kinases contribute to GPx-mediated protection of cells against oxidative stress. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPARGC1A | up-regulates
|
GPX1 |
0.322 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253396 |
|
|
Mus musculus |
|
pmid |
sentence |
18074631 |
In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
|
Publications: |
1 |
Organism: |
Mus Musculus |