Summary

Name ITGA2B
Full Name Integrin alpha-IIb
Synonyms GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb | GP2B, ITGAB
Primary ID P08514
Links - -
Type protein
Relations 4
Function Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA2B 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITGA2B 0.488
Publications: 1 Organism: Cricetulus Griseus
+ form complex img/form-complex.png binding AIIB/b3 integrin 0.946
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA2B 0.469
Publications: 1 Organism: Homo Sapiens