Summary

Name CSF1
Full Name Macrophage colony-stimulating factor 1
Synonyms CSF-1, M-CSF, MCSF, Lanimostim
Primary ID P09603
Links - -
Type protein
Relations 4
Pathways Monocyte: Macrophage differentiation
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding CSF1R 0.937
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CSF1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSF3R 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSF2RA 0.34
Publications: 1 Organism: Homo Sapiens