3.0
Summary
| Name |  VDRView Modifications |
| Full Name | Vitamin D3 receptor |
| Synonyms | VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 | NR1I1 |
| Primary ID | P11473 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | up-regulates 
phosphorylation
|
VDR | 0.342 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VDR | down-regulates quantity by repression 
transcriptional regulation
|
CYP24A1 | 0.584 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VDR | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DRB1 | 0.31 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ZEB2 | up-regulates quantity by expression
transcriptional regulation
|
VDR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNAI2 | down-regulates quantity by repression
transcriptional regulation
|
VDR | 0.382 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CTBP1 | down-regulates quantity by repression
transcriptional regulation
|
VDR | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VDR | up-regulates quantity by expression
transcriptional regulation
|
CYP3A4 | 0.414 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
VDR | 0.393 |
| Publications: | 1 | Organism: | Homo Sapiens | |