Summary

Name IGF2R
Full Name Cation-independent mannose-6-phosphate receptor
Synonyms CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R | MPRI
Primary ID P11717
Links - -
Type protein
Relations 11
Function Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation IGF2R 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IGF2R 0.49
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization IGF2R 0.714
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity img/direct_inhibition.png binding IGF2R 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding IGF2R 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization IGF2R 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IGF2R 0.419
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization IGF2R 0.352
Publications: 1
+ up-regulates img/direct-activation.png binding IGF2R 0.758
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization IGF2R 0.507
Publications: 1