| + |
PRKCA |
phosphorylation
|
VCL |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249128 |
Ser1101 |
NAQNLMQsVKETVRE |
in vitro |
|
| pmid |
sentence |
| 11741957 |
PKC Phosphorylates Serines 1033 and 1045 in Helix H5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249129 |
Ser1113 |
VREAEAAsIKIRTDA |
in vitro |
|
| pmid |
sentence |
| 11741957 |
PKC Phosphorylates Serines 1033 and 1045 in Helix H5 |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
SRC | down-regulates activity 
phosphorylation
|
VCL |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247424 |
Tyr100 |
QMLQSDPySVPARDY |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15229287 |
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreadingWhen phosphorylated, the vinculin tail exhibited significantly less binding to the vinculin head domain than the unphosphorylated tail. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247428 |
Tyr1133 |
WVRKTPWyQ |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15229287 |
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreadingWhen phosphorylated, the vinculin tail exhibited significantly less binding to the vinculin head domain than the unphosphorylated tail. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
PTPRG | down-regulates activity
dephosphorylation
|
VCL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254731 |
Tyr822 |
KSFLDSGyRILGAVA |
in vitro |
|
| pmid |
sentence |
| 25624455 |
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ABL1 | up-regulates activity 
phosphorylation
|
VCL |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278464 |
Tyr822 |
KSFLDSGyRILGAVA |
Homo sapiens |
|
| pmid |
sentence |
| 24751539 |
Abl is the tyrosine kinase that phosphorylates vinculin Y822.|Finally we show that Abl inhibition prevents vinculin actions in cadherin containing complexes, resulting in defects in cell stiffening. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
VCL
- 
- 