Summary

Name PTPRA
Full Name Receptor-type tyrosine-protein phosphatase alpha
Synonyms Protein-tyrosine phosphatase alpha, R-PTP-alpha | PTPA, PTPRL2
Primary ID P18433
Links - -
Type protein
Relations 12
Function Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PTPRA 0.333
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation LYN 0.306
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.731
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FYN 0.641
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.641
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTPRA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPRA 0.731
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PTPRA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation KCNB1 0.2
Publications: 1 Organism: Homo Sapiens