Summary

Name GABRG2
Full Name Gamma-aminobutyric acid receptor subunit gamma-2
Synonyms GABA(A) receptor subunit gamma-2 |
Primary ID P18507
Links - -
Type protein
Relations 7
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation GABRG2 0.236
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding GABA-A (a1-b1-g2) receptor 0.635
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding GABA-A (a5-b1-g2) receptor 0.628
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding GABA-A (a4-b1-g2) receptor 0.619
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding GABA-A (a3-b1-g2) receptor 0.614
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding GABA-A (a2-b1-g2) receptor 0.616
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ form complex img/form-complex.png binding GABA-A (a6-b1-g2) receptor 0.619
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System