+ |
GRK2 | up-regulates activity
phosphorylation
|
PDE6G |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-247823 |
Thr62 |
PGMEGLGtDITVICP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
12624098 |
Mutation of Thr-62 (to Ala) in PDEgamma produced a GRK2 phosphorylation-resistant mutant that was less effective in associating with GRK2 in response to epidermal growth factor and did not potentiate the stimulation of p42/p44 mitogen-activated protein kinase by this growth factor. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251459 |
Thr62 |
PGMEGLGtDITVICP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11502744 |
Rod PDEγ is predominantly phosphorylated by GRK2 at the Thr-62. GRK2 is required for the stimulatory effect of rod PDEγ on both the EGF- and thrombin-dependent activation of p42/p44 MAPK |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PDE6G | down-regulates activity
binding
|
PDE6A |
0.861 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260010 |
|
|
Homo sapiens |
|
pmid |
sentence |
20940301 |
Both PDE6C-A and PDE6C-B were potently and similarly inhibited by both Pγ subunits, with Ki values ranging from 33 to 46 pm (Fig. 5). The inhibition analysis revealed no significant differences between PDE6C-A and PDE6C-B |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GNAT1 | down-regulates activity
binding
|
PDE6G |
0.755 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260008 |
|
|
Mus musculus |
|
pmid |
sentence |
30962282 |
In the dark, PDE6 activity is suppressed by its inhibitory γ-subunit (Pγ). Rhodopsin-catalyzed activation of the G protein, transducin, relieves this inhibition and enhances PDE6 catalysis. |
|
Publications: |
1 |
Organism: |
Mus Musculus |