| + |
CSNK2A1 | up-regulates activity 
phosphorylation
|
XRCC1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250972 |
Ser475 |
IDIEGVQsEGQDNGA |
Cricetulus griseus |
CHO-EM9 Cell |
| pmid |
sentence |
| 15066279 |
We show that inhibiting XRCC1 phosphorylation by mutation of the CK2 phosphorylation sites or preventing CK2 activity using a highly specific inhibitor ablates the rapid repair of cellular DNA single-strand breaks by XRCC1. | |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
CSNK2A1 | up-regulates
phosphorylation
|
XRCC1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165419 |
Ser485 |
QDNGAEDsGDTEDEL |
Homo sapiens |
|
| pmid |
sentence |
| 20471329 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165423 |
Ser518 |
GEDPYAGsTDENTDS |
Homo sapiens |
|
| pmid |
sentence |
| 20471329 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair. Rcc1 is phosphorylated in vivo and in vitro by ck2, and ck2 phosphorylation of xrcc1 on s518, t519, and t523 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128893 |
Ser518 |
GEDPYAGsTDENTDS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15367657 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair. Rcc1 is phosphorylated in vivo and in vitro by ck2, and ck2 phosphorylation of xrcc1 on s518, t519, and t523 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165427 |
Thr488 |
GAEDSGDtEDELRRV |
Homo sapiens |
|
| pmid |
sentence |
| 20471329 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165431 |
Thr519 |
EDPYAGStDENTDSE |
Homo sapiens |
|
| pmid |
sentence |
| 20471329 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair. Rcc1 is phosphorylated in vivo and in vitro by ck2, and ck2 phosphorylation of xrcc1 on s518, t519, and t523 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128897 |
Thr519 |
EDPYAGStDENTDSE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15367657 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair. Rcc1 is phosphorylated in vivo and in vitro by ck2, and ck2 phosphorylation of xrcc1 on s518, t519, and t523 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165435 |
Thr523 |
AGSTDENtDSEEHQE |
Homo sapiens |
|
| pmid |
sentence |
| 20471329 |
Xrcc1 phosphorylation by ck2 is required for its stability and efficient dna repair. Rcc1 is phosphorylated in vivo and in vitro by ck2, and ck2 phosphorylation of xrcc1 on s518, t519, and t523 |
|
| Publications: |
7 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 | up-regulates activity
phosphorylation
|
XRCC1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251050 |
Ser518 |
GEDPYAGsTDENTDS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15367657 |
XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of XRCC1 on S518, T519, and T523 largely determines aprataxin binding to XRCC1 though its FHA domain | In addition, we present data to show that the acute loss of aprataxin by small interfering RNA (siRNA) renders HeLa cells sensitive to MMS through a mechanism that destabilizes XRCC1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251051 |
Thr519 |
EDPYAGStDENTDSE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15367657 |
XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of XRCC1 on S518, T519, and T523 largely determines aprataxin binding to XRCC1 though its FHA domain | In addition, we present data to show that the acute loss of aprataxin by small interfering RNA (siRNA) renders HeLa cells sensitive to MMS through a mechanism that destabilizes XRCC1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251052 |
Thr523 |
AGSTDENtDSEEHQE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15367657 |
XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of XRCC1 on S518, T519, and T523 largely determines aprataxin binding to XRCC1 though its FHA domain | In addition, we present data to show that the acute loss of aprataxin by small interfering RNA (siRNA) renders HeLa cells sensitive to MMS through a mechanism that destabilizes XRCC1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CHEK2 | up-regulates
phosphorylation
|
XRCC1 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181816 |
Thr284 |
APTRTPAtAPVPARA |
Homo sapiens |
|
| pmid |
sentence |
| 18971944 |
Chk2 formed a complex with xrcc1, the ber scaffold protein, and phosphorylated xrcc1 in vivo and in vitro at thr(284). our results are consistent with the phosphorylation of xrcc1 by atm-chk2 facilitating recruitment of downstream ber proteins to the initial damage recognition/excision step to promote ber. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
XRCC1
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