3.0
Summary
| Name |  ERCC3View Modifications |
| Full Name | General transcription and DNA repair factor IIH helicase subunit XPB |
| Synonyms | Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH 89 kDa subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein | XPB, XPBC |
| Primary ID | P19447 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation (PubMed:8157004, PubMed:30894545). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates activity 
phosphorylation
|
ERCC3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CDK7 | down-regulates quantity by destabilization
phosphorylation
|
ERCC3 | 0.891 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXL18 | down-regulates quantity by destabilization
binding
|
ERCC3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERCC3 | form complex 
binding
|
TFIIH | 0.887 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
ERCC3 | 0.397 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERCC2 | up-regulates 
binding
|
ERCC3 | 0.954 |
| Publications: | 1 | Organism: | Homo Sapiens | |