4.0
Summary
| Name |  CCNA2View Modifications |
| Full Name | Cyclin-A2 |
| Synonyms | Cyclin-A | CCN1, CCNA |
| Primary ID | P20248 |
| Links |  -  -  |
| Type | protein |
| Relations | 18 |
| Inhibitors | seliciclib; PHA-848125; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK2 | up-regulates 
phosphorylation
|
CCNA2 | 0.977 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | seliciclib | down-regulates 
chemical inhibition
|
CCNA2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHA-848125 | down-regulates
chemical inhibition
|
CCNA2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC25A | up-regulates activity
dephosphorylation
|
CCNA2 | 0.695 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide | down-regulates
chemical inhibition
|
CCNA2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEK5 | up-regulates activity
binding
|
CCNA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YAP/TAZ | up-regulates quantity by expression 
transcriptional regulation
|
CCNA2 | 0.2 |
| Publications: | 1 | |||
| + | SMARCB1 | down-regulates 
|
CCNA2 | 0.344 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | APC-c | down-regulates quantity by destabilization
ubiquitination
|
CCNA2 | 0.56 |
| Publications: | 1 | |||
| + | CCNA2 | form complex 
binding
|
CyclinA2/CDK2 | 0.977 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
CCNA2 | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYC | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 | 0.418 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YAP1 | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 | 0.324 |
| Publications: | 1 | |||
| Tissue: | MCF-10A Cell | |||
| + | HMGA2 | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 | 0.312 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP37 | up-regulates quantity by stabilization
deubiquitination
|
CCNA2 | 0.582 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCNA2 | form complex
binding
|
CyclinA2/CDK18 | 0.392 |
| Publications: | 1 | |||
| + | 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide | down-regulates
chemical inhibition
|
CCNA2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCNA2 | form complex
binding
|
CyclinA2/CDK1 | 0.923 |
| Publications: | 1 | Organism: | Homo Sapiens | |