| + |
PRKCD | down-regulates 
phosphorylation
|
C5AR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73967 |
Ser334 |
SVVRESKsFTRSTVD |
Homo sapiens |
|
| pmid |
sentence |
| 10636859 |
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151015 |
Ser334 |
SVVRESKsFTRSTVD |
Homo sapiens |
|
| pmid |
sentence |
| 17145764 |
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96067 |
Ser334 |
SVVRESKsFTRSTVD |
Homo sapiens |
|
| pmid |
sentence |
| 12464600 |
Whole cell phosphorylation assays with specific inhibitors as well as in vitro phosphorylation assays with recombinant enzymes and peptide substrates revealed that phosphorylation of ser-334 is regulated by protein kinase c-beta this study is among the first to analyze in a detailed manner, using a non-mutational approach, modifications of a defined phosphorylation site in a g protein-coupled receptor and to correlate these findings with functional parameters of receptor deactivation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKCB | down-regulates
phosphorylation
|
C5AR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151011 |
Ser334 |
SVVRESKsFTRSTVD |
Homo sapiens |
|
| pmid |
sentence |
| 17145764 |
Dynamics of protein kinase c-mediated phosphorylation of the complement c5a receptor on serine 334. Analysis of c5ar ser/ala mutants that possess a single intact serine residue either at position 334 or at neighboring positions 327, 332, or 338 revealed functional redundancy of c-terminal phosphorylation sites since all 4 serine residues could individually support c5ar internalization and desensitization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C5AR1 | up-regulates 
|
Chemotaxis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9108406 |
We report here that the anaphylatoxins C3a and C5a are chemotactic factors for the human mast cell line HMC-1, human cord blood-derived mast cells (CBMC) and cutaneous mast cells in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C5 | up-regulates activity 
binding
|
C5AR1 |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1847994 |
The chemotactic receptor for human C5a anaphylatoxin|The human C5a receptor was cloned from U937 and HL-60 cells and identified by high affinity binding when expressed in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C5AR1 | up-regulates quantity by expression
|
superoxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263469 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| Pathways: | Complement Signaling |
| + |
C5AR1 | up-regulates quantity by expression
|
CR1 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263466 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
C5AR1 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263462 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| Pathways: | Complement Signaling |
| + |
C5AR1 | down-regulates quantity by repression 
|
SELL |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263468 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
Avacopan | down-regulates activity
binding
|
C5AR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31734405 |
CCX168 (avocapan), a C5aR antagonist, has proven its safety and efficiency in phase I and phase II trials conducted in AAV patients. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C5AR1 | up-regulates quantity by expression
|
ITGAM |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263464 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
3.0
C5AR1
- 
- 