3.0
Summary
| Name |  VDAC1View Modifications |
| Full Name | Voltage-dependent anion-selective channel protein 1 |
| Synonyms | VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM | VDAC |
| Primary ID | P21796 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NEK1 | down-regulates 
phosphorylation
|
VDAC1 | 0.436 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAX | up-regulates activity 
binding
|
VDAC1 | 0.574 |
| Publications: | 1 | |||
| + | SOD1 | down-regulates activity
binding
|
VDAC1 | 0.437 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Spinal Cord | |||
| + | BCL2L1 | down-regulates activity
binding
|
VDAC1 | 0.584 |
| Publications: | 1 | |||
| + | TSPO2 | up-regulates activity
binding
|
VDAC1 | 0.315 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VDAC1 | up-regulates 
|
Apoptosis | 0.7 |
| Publications: | 1 | |||
| + | FAM162A | up-regulates activity
binding
|
VDAC1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |