| + |
CSNK1A1 | down-regulates activity 
phosphorylation
|
YWHAQ |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250795 |
Ser232 |
LTLWTSDsAGEECDA |
in vitro |
|
| pmid |
sentence |
| 9360956 |
This protein kinase has been identified as casein kinase Ialpha (CKIalpha) by peptide mapping analysis and sequencing. Among mammalian 14-3-3, only 14-3-3 tau possesses a phosphorylatable residue at the same position (Ser-233), and we show that this residue is also phosphorylated by CKI. In addition, we show that 14-3-3 zeta is exclusively phosphorylated on Thr-233 in human embryonic kidney 293 cells. The residue 233 is located within a region shown to be important for the association of 14-3-3 to target proteins. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CSNK2A1 | down-regulates activity
phosphorylation
|
YWHAQ |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264405 |
Ser232 |
LTLWTSDsAGEECDA |
Homo sapiens |
|
| pmid |
sentence |
| 25862939 |
The neuroprotective effect of 14-3-3theta against rotenone toxicity is dependent on the inhibition of the pro-apoptotic factor Bax|Phosphorylation at S232 induced by rotenone is reduced by casein kinase inhibitors, and is not dependent on alphasyn.| The S232D mutant partially reduced the ability of 14-3-3theta to inhibit Bax activation in response to rotenone. Based on these findings, we propose that phosphorylation of 14-3-3s at serine 232 contributes to the neurodegenerative process in PD. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCR |
phosphorylation
|
YWHAQ |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250594 |
Ser232 |
LTLWTSDsAGEECDA |
in vitro |
|
| pmid |
sentence |
| 16045749 |
We show here that BCR interacts with at least five isoforms of 14-3-3 in vivo and phosphorylates 14-3-3tau on Ser233 and to a lesser extent 14-3-3zeta on Thr233 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YWHAQ | down-regulates
relocalization
|
CDC25C |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20068082 |
Cdc25c: nuclear exclusion/cytoplasmic sequestration via binding to 14-3-3 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YWHAQ | up-regulates quantity by stabilization 
binding
|
GEM |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261714 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14701738 |
In order to address whether Gem binds specific isoforms of 14-3-3, we determined the coassociation of Gem and 14-3-3 in the neuroblastoma cell line SY5Y. 14-3-3ζ, -γ, -τ, and -β were observed to bind to Gem. 14-3-3-bound Gem has a twofold-longer half-life than nonbound Gem (Fig. (Fig.6).6). A similar increase in protein stability following 14-3-3 binding has been described for the Wee1 kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261724 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14701738 |
In order to address whether Gem binds specific isoforms of 14-3-3, we determined the coassociation of Gem and 14-3-3 in the neuroblastoma cell line SY5Y. 14-3-3ζ, -γ, -τ, and -β were observed to bind to Gem. 14-3-3-bound Gem has a twofold-longer half-life than nonbound Gem (Fig. (Fig.6).6). A similar increase in protein stability following 14-3-3 binding has been described for the Wee1 kinase |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
YWHAQ | down-regulates
binding
|
CDKN1B |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12042314 |
14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YWHAQ | down-regulates 
|
PRKD1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65951 |
|
|
in vitro |
|
| pmid |
sentence |
| 10092600 |
14-3-3tau strongly down-regulates pkcmu kinase activity in vitro |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YWHAQ | down-regulates activity
binding
|
NEFL |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23230147 |
These results suggest the important role of 14-3-3 in the dynamic regulation of NF-L assembly, and in the capacity to prevent the formation of NF-L aggregates. all seven isoforms specifically interacted with NF-L, but not NF-M or NF-H. specific interaction of 14-3-3 proteins with phosphorylated NF-L subunits also indicated the role of 14-3-3 and NF-L phosphorylation in the disassembly of neurofilaments. What is more, binding of 14-3-3 to phosphorylated NF-L subunits may prevent the dephosphorylation of these subunits by phosphatases, maintaining the hyperphosphorylation state of the subunits, which facilitates the disassembly of neurofilaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YWHAQ | up-regulates
binding
|
MEF2D |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11433030 |
14-3-3tau associates with and activates the mef2d transcription factor during muscle cell differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
YWHAQ
- 
- 