Summary

Name EPHA3
Full Name Ephrin type-A receptor 3
Synonyms EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1 | ETK, ETK1, HEK, TYRO4
Primary ID P29320
Links - -
Type protein
Relations 10
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation EPHA3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EPHA3 0.424
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CRK 0.613
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.809
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.942
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.795
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRC 0.51
Publications: 1 Organism: Homo Sapiens