Relation Results

Summary

Name EPHB2
Full Name Ephrin type-B receptor 2
Synonyms Developmentally-regulated Eph-related tyrosine kinase, ELK-related tyrosine kinase, EPH tyrosine kinase 3, EPH-like kinase 5, EK5, hEK5, Renal carcinoma antigen NY-REN-47, Tyrosine-protein kinase TYRO5, Tyrosine-protein kinase receptor EPH-3 | DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5
Primary ID P29323
Links - -
Type protein
Relations 9
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidi ...
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Type: Score: Layout: SPV 
0.3010.4940.20.6010.20.5580.5530.5040.565EPHB2NRCAMARHGEF15RRASBTF3SYNJ1SRCABL1RASA1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ EPHB2up-regulates activity img/direct-activation.png phosphorylation NRCAM 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-262863 Tyr1276 DGSFIGQySGKKEKE Homo sapiens HEK-293 Cell
pmid sentence
EphB receptors were found to induce phosphorylation of NrCAM on the tyrosine residue within the FIGQY ankyrin binding motif, inhibiting ankyrin recruitment. Furthermore, NrCAM phospho-FIGQY levels in the SC were decreased in EphB1/3 and EphB1/2/3 null mice and increased in mutant mice overexpressing constitutively active EphB2 kinase. 
Publications: 1 Organism: Homo Sapiens
+ EPHB2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ARHGEF15 0.494
Identifier Residue Sequence Organism Cell Line
SIGNOR-262864 Tyr353 PLQDEPLyQTYRAAV Homo sapiens HEK-293 Cell
pmid sentence
We have identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor tyrosine kinase triggers Ephexin5 phosphorylation, ubiquitination, and degradation. EphB2 mediates phosphorylation of Ephexin5 at tyrosine-361
Publications: 1 Organism: Homo Sapiens
+ EPHB2up-regulates activity img/direct-activation.png phosphorylation EPHB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251124 Tyr602 IYIDPFTyEDPNEAV in vitro
pmid sentence
Our results demonstrate that autophosphorylation tyrosine 611 in the juxtamembrane region of chicken EphB2 is critical for the association of the Src SH2 domain.
Publications: 1 Organism: In Vitro
+ EPHB2down-regulates activity img/direct_inhibition.png phosphorylation RRAS 0.601
Identifier Residue Sequence Organism Cell Line
SIGNOR-251125 Tyr66 DPTIEDSyTKICSVD Homo sapiens
pmid sentence
Tyrosine 66 of R-Ras is phosphorylated by EphB2|. R-Ras, a small intracellular GTPase, regulates the binding of integrins to their ligands outside the cell. |Cells in which EphB2 is activated become poorly adherent to substrates coated with integrin ligands, and a tyrosine residue in the R-Ras effector domain is phosphorylated.
Publications: 1 Organism: Homo Sapiens
+ BTF3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EPHB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253949 Homo sapiens Pancreatic Cancer Cell
pmid sentence
In contrast, BTF3 silencing resulted in down-regulation of several cancer-associated genes, including EPHB2, ABL2, HPSE2 and ATM, and up-regulation of KRAG, RRAS2, NFkappa-B, MRVI1, MADCAM1 and others. In conclusion, BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis.
Publications: 1 Organism: Homo Sapiens
+ EPHB2down-regulates img/direct_inhibition.png phosphorylation SYNJ1 0.558
Identifier Residue Sequence Organism Cell Line
SIGNOR-135274 Homo sapiens Neuron
pmid sentence
Ephb2 causes tyrosine phosphorylation in the proline-rich domain of synaptojanin 1, and inhibits both the interaction with endophilin and the 5'-phosphatase activity of synaptojanin 1
Publications: 1 Organism: Homo Sapiens
+ EPHB2up-regulates img/direct-activation.png binding SRC 0.553
Identifier Residue Sequence Organism Cell Line
SIGNOR-58142 Homo sapiens
pmid sentence
We propose src kinase as a downstream effector that mediates the neuron's response to eph receptor activation
Publications: 1 Organism: Homo Sapiens
+ ABL1down-regulates img/direct_inhibition.png phosphorylation EPHB2 0.504
Identifier Residue Sequence Organism Cell Line
SIGNOR-109668 Homo sapiens Neuron
pmid sentence
Two-hybrid screens identified regions of abl and arg that bind to the ephb2 and epha4 receptors, suggesting a novel signaling connection involving the two kinase families.The connection between EphB2 and Abl/Arg appears to be reciprocal. Activated EphB2 causes tyrosine phosphorylation of Abl and Arg, and vice versa. Interestingly, treatment of COS cells and B35 neuronal-like cells with ephrin-B1 to activate endogenous EphB2 decreased the kinase activity of endogenous Abl.
Publications: 1 Organism: Homo Sapiens
+ EPHB2up-regulates img/direct-activation.png binding RASA1 0.565
Identifier Residue Sequence Organism Cell Line
SIGNOR-50100 Homo sapiens
pmid sentence
We have localized an in vitro rasgap-binding site to conserved tyrosine residues y604 and y610 in the juxtamembrane region of ephb2, and demonstrated that substitution of these amino acids abolishes ephrin-b1-induced signalling events in ephb2-expressing ng108-15 cells.
Publications: 1 Organism: Homo Sapiens
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