| + |
GSK3B | down-regulates 
phosphorylation
|
CCND2 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154668 |
Thr280 |
DELDQAStPTDVRDI |
Homo sapiens |
|
| pmid |
sentence |
| 17486076 |
Glycogen synthase kinase-3beta and p38 phosphorylate cyclin d2 on thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROBO | down-regulates
phosphorylation
|
CCND2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154672 |
Thr280 |
DELDQAStPTDVRDI |
Homo sapiens |
|
| pmid |
sentence |
| 17486076 |
These results indicate that cyclin d2 expression in normal and malignant hematopoietic cells is regulated by ubiquitin/proteasome-dependent degradation that is triggered by thr280 phosphorylation by gsk3beta or p38 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CCND2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272007 |
|
|
Mus musculus |
MLE-12 Cell |
| pmid |
sentence |
| 22323446 |
F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Purified SCF complex components were incubated with V5-cyclin D2 and the full complement of ubiquitination reaction components (second lane from left) showing polyubiquitinated cyclin D2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FUBP1 | up-regulates quantity by expression 
transcriptional regulation
|
CCND2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
A positive cell cycle regulator that we found down-regulated in Hep3B cells upon FBP1 inactivation was cyclin D2. In addition, Cyclin D2 mRNA levels were diminished in the FBP1 knockdown cells, whereas the amount of Cyclin D1 mRNA remained unaffected. Numerous studies have classified D-type cyclins as cell cycle–promoting oncoproteins important for cellular transformation, and our results suggest that cyclin D2 is a candidate FBP1-regulated oncoprotein in HCC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-1-5p | down-regulates quantity by repression
post transcriptional regulation
|
CCND2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277929 |
|
|
Homo sapiens |
Thyroid Cancer Cell |
| pmid |
sentence |
| 21752897 |
This result indicates that miR-1 affects CCND2 protein synthesis by facilitating the specific degradation of CCND2 mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
palbociclib | down-regulates
chemical inhibition
|
CCND2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCT1 | down-regulates quantity by repression 
transcriptional regulation
|
CCND2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30283340 |
MYCT1 overexpression significantly inhibited cell proliferation, arrested cell cycle at G0/G1 phase, and downregulated the expression of cyclins D and E. Moreover, MYCT1 overexpression triggered apoptosis in AML cells, which was accompanied by enhanced cleavage of caspase-3 and -9, upregulated expression of B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and downregulated Bcl-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXL2 | down-regulates quantity by destabilization
binding
|
CCND2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272006 |
|
|
Mus musculus |
MLE-12 Cell |
| pmid |
sentence |
| 22323446 |
F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Purified SCF complex components were incubated with V5-cyclin D2 and the full complement of ubiquitination reaction components (second lane from left) showing polyubiquitinated cyclin D2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXL2 | down-regulates quantity by repression
transcriptional regulation
|
CCND2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21862621 |
We previously demonstrated that FOXL2 is a transcriptional repressor of the steroidogenic acute regulatory (StAR), P450SCC (CYP11A), P450aromatase (CYP19), and cyclin D2 (CCND2) genes, markers of ovarian follicle proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression 
transcriptional regulation
|
CCND2 |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7526316 |
C-myc directly activates transcription of cyclin d1, cyclin d2 and cdk4, and leads to cdk 4/6 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCND2
- 
- 