Summary
Name | AXL View Modifications |
Full Name | Tyrosine-protein kinase receptor UFO |
Synonyms | AXL oncogene | UFO |
Primary ID | P30530 |
Links | - - |
Type | protein |
Relations | 10 |
Inhibitors | N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; cabozantinib; N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide |
Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | AXL | up-regulates quantity by stabilization phosphorylation | MLKL | 0.2 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | AXL | up-regulates activity phosphorylation | AXL | 0.2 |
Publications: | 3 | Organism: | In Vitro | |
+ | PROS1 | up-regulates binding | AXL | 0.485 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | down-regulates activity chemical inhibition | AXL | 0.8 |
Publications: | 1 | Organism: | In Vitro | |
+ | cabozantinib | down-regulates activity chemical inhibition | AXL | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide | down-regulates chemical inhibition | AXL | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | GAS6 | up-regulates binding | AXL | 0.907 |
Publications: | 2 | Organism: | Homo Sapiens | |