| + |
HOXD11 | up-regulates activity 
binding
|
MEIS1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241229 |
|
|
in vitro |
|
| pmid |
sentence |
| 9343407 |
We now show that the Hoxa-9 protein physically interacts with Meis1 proteins. Hox proteins from the other AbdB-like paralogs, Hoxa-10, Hoxa-11, Hoxd-12, and Hoxb-13, also form DNA binding complexes with Meis1b. DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with Meis1 alone, suggesting that Hox proteins stabilize the interactions of Meis1 proteins with their DNA targets. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
POU2F1 | up-regulates quantity by expression 
transcriptional regulation
|
HOXD11 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25301728 |
Knockdown of pou2f1 significantly reduced expression of hoxd10 and d11 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGB1 | up-regulates activity
binding
|
HOXD11 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240559 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
HOXD11
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