| Name
|
 Ptpn11
|
| Full Name |
Tyrosine-protein phosphatase non-receptor type 11 |
| Synonyms |
Protein-tyrosine phosphatase SYP, SH-PTP2, SHP-2, Shp2 | |
| Primary ID |
P35235 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). |
3.0