3.0
Summary
| Name |  CASRView Modifications |
| Full Name | Extracellular calcium-sensing receptor |
| Synonyms | CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1 | GPRC2A, PCAR1 |
| Primary ID | P41180 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCB | down-regulates activity 
phosphorylation
|
CASR | 0.323 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCA | down-regulates
phosphorylation
|
CASR | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GCM2 | up-regulates quantity by expression 
transcriptional regulation
|
CASR | 0.471 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||
| + | RNF19A | down-regulates quantity by destabilization
ubiquitination
|
CASR | 0.39 |
| Publications: | 1 | Organism: | Homo Sapiens | |