| + |
p38 | up-regulates 
phosphorylation
|
HNF4A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143046 |
Ser167 |
VLSRQITsPVSGING |
Homo sapiens |
|
| pmid |
sentence |
| 16351573 |
Our results indicate that p38 kinase-mediated ser158 phosphorylation is essential for augmentation of the dna binding and transactivation potential of hnf4alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates activity 
phosphorylation
|
HNF4A |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263106 |
Ser303 |
DPDAKGLsDPGKIKR |
in vitro |
|
| pmid |
sentence |
| 12740371 |
Here we demonstrate that AMPK directly phosphorylates HNF4alpha and represses its transcriptional activity. AMPK-mediated phosphorylation of HNF4alpha on serine 304 had a 2-fold effect, reducing the ability of the transcription factor to form homodimers and bind DNA and increasing its degradation rate in vivo. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AMPK | down-regulates
phosphorylation
|
HNF4A |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216511 |
Ser303 |
DPDAKGLsDPGKIKR |
Homo sapiens |
|
| pmid |
sentence |
| 12740371 |
Here we demonstrate that ampk directly phosphorylates hnf4 and represses its transcriptional activity. Ampk-mediated phosphorylation of hnf4 on serine 304 had a 2-fold effect |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
HNF4A |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101101 |
Ser303 |
DPDAKGLsDPGKIKR |
Homo sapiens |
|
| pmid |
sentence |
| 12740371 |
Here we demonstrate that ampk directly phosphorylates hnf4 and represses its transcriptional activity. Ampk-mediated phosphorylation of hnf4 on serine 304 had a 2-fold effect |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA2 | down-regulates quantity by destabilization
phosphorylation
|
HNF4A |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250322 |
Ser313 |
GKIKRLRsQVQVSLE |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12740371 |
AMPK directly phosphorylates HNF4alpha and represses its transcriptional activity. AMPK-mediated phosphorylation of HNF4alpha on serine 304 had a 2-fold effect, reducing the ability of the transcription factor to form homodimers and bind DNA and increasing its degradation rate in vivo. Phosphorylation of HNF4α on Ser-304 reduces protein stability. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SRC | down-regulates
phosphorylation
|
HNF4A |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195883 |
Tyr23 |
SAALDPAyTTLEFEN |
Homo sapiens |
|
| pmid |
sentence |
| 22308320 |
Here we show that c-src phosphorylates human hnf4_ on three tyrosines phosphomimetic mutants in the lbd decrease p1-hnf4_ protein stability, nuclear localization and transactivation function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195896 |
Tyr286 |
LQIDDNEyAYLKAII |
Homo sapiens |
|
| pmid |
sentence |
| 22308320 |
Here we show that c-src phosphorylates human hnf4_ on three tyrosines phosphomimetic mutants in the lbd decrease p1-hnf4_ protein stability, nuclear localization and transactivation function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195900 |
Tyr288 |
IDDNEYAyLKAIIFF |
Homo sapiens |
|
| pmid |
sentence |
| 22308320 |
Here we show that c-src phosphorylates human hnf4_ on three tyrosines phosphomimetic mutants in the lbd decrease p1-hnf4_ protein stability, nuclear localization and transactivation function. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression 
transcriptional regulation
|
AKR1C4 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240016 |
|
|
Homo sapiens |
ACHN Cell |
| pmid |
sentence |
| 2044952 |
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-4_ is a necessary factor for the activation of the human DD4 gene. is much higher than that of vHNF-1-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
PCSK9 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254451 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
all-trans-retinoic acid | down-regulates quantity by repression 
|
HNF4A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9792724 |
Retinoic acid mediates down-regulation of the alpha-fetoprotein gene through decreased expression of hepatocyte nuclear factors. The levels of HNF1 and HNF4 mRNA were also decreased following RA treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181271 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
PCK1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Pgc1alfa is thought to mediate transcription downstream of the nuclear receptor hepatocyte nuclear factor 4alfa (hnf4alfa) and the transcription factor foxo1 in the promoters of key gluconeogenic enzymes, including glucose-6-phosphatase (g6pase) and phosphoenolpyruvate carboxylase (pepck) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
NPC1L1 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Our results showed a positive correlation between changes in NPC1L1 and changes in both SREBP-2 and HNF-4α mRNA expression, a finding that supports the notion that these transcription factors stimulate intestinal NPC1L1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
C1QTNF5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254448 |
|
|
Homo sapiens |
Liver Cell Line |
| pmid |
sentence |
| 20621834 |
Here we demonstrate the mechanism by which the CTRP5 gene is transcriptionally activated in the liver. CTRP5 is activated by HNF4alpha via the region -206/-167 of the human CTRP5 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | down-regulates quantity by repression
transcriptional regulation
|
ABCG5 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254457 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
AFP |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254446 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 9792724 |
AFP promoter-chloramphenicol acetyltransferase transient transfection assays demonstrated that the level of HNF1 had a direct impact on basal transcription as well as RA-mediated down-regulation of the AFP gene, and that co-transfection of HNF1 and HNF4, but not transfection of either factor alone, reversed the RA-mediated inhibition. Taken together these data point to an interaction among the RA, HNF1, and HNF4 signals, which is reflected in decreased expression of AFP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
GK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18805788 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
LDLR |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254454 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | down-regulates quantity by repression
transcriptional regulation
|
ABCG8 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254458 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
CYP27A1 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255198 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 11867220 |
Therefore, Sp1, Sp3 and HNF4 co-operate in the expression of the human CYP27 gene in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
HNF4A |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10594021 |
Here we show that shp inhibits transactivation by the orphan receptor hepatocyte nuclear factor 4 (hnf-4) and the retinoid x receptor (rxr) by at least two mechanisms shp also competes with coactivators for binding to ligand-activated rxr, and based on the ligand-dependent interaction with other nuclear receptors, it is likely that coactivator competition is a general feature of shp-mediated repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
HNF4A |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17978169 |
Electrophoretic mobility shift, chromatin immunoprecipitation (ChIP), and streptavidin DNA binding assays revealed that DEX increased binding of HNF4alpha to the HNF4-RE and that an interaction of GR and HNF4alpha occurred at this site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
HNF4A | down-regulates quantity by repression
transcriptional regulation
|
F12 |
0.221 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254073 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9794469 |
Orphan receptor hepatocyte nuclear factor-4 antagonizes estrogen receptor alpha-mediated induction of human coagulation factor XII gene. In conclusion, our findings address a direct role for HNF-4 in modulating estrogen-dependent transcription of the FXII gene promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | down-regulates quantity by repression
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254449 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18513187 |
We also confirmed that activation and repression of hHSS transcription induced by Sp1 and HNF4alpha resulted from binding of these factors to these two cis-elements respectively. Overexpression of HNF4alpha led to a dramatic repression of the promoter activity and, in contrast, the activity was markedly elevated by overexpression of Sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HNF4A
- 
- 