+ |
CSNK2A1 | down-regulates activity
phosphorylation
|
CDC34 |
0.403 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-110383 |
Ser203 |
APAPDEGsDLFYDDY |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
The ubiquitin-conjugating enzyme, cdc34, has been implicated in the ubiquitination of a number of vertebrate substrates, including p27(kip1), ikappabalpha, wee1, and myod. We show that mammalian cdc34 is a phosphoprotein that is phosphorylated in proliferating cells. Phosphorylation of cdc34 by the associated kinase maps predominantly to residues 203 and 222. Mutation of cdc34 at ck2-targeted residues, ser-203, ser-222, ser-231, thr-233, and ser-236, abolishes the phosphorylation of cdc34 observed in vivo and markedly shifts nuclearly localized cdc34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-110395 |
Ser222 |
EVEEEADsCFGDDED |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
The ubiquitin-conjugating enzyme, cdc34, has been implicated in the ubiquitination of a number of vertebrate substrates, including p27(kip1), ikappabalpha, wee1, and myod. We show that mammalian cdc34 is a phosphoprotein that is phosphorylated in proliferating cells. Phosphorylation of cdc34 by the associated kinase maps predominantly to residues 203 and 222. Mutation of cdc34 at ck2-targeted residues, ser-203, ser-222, ser-231, thr-233, and ser-236, abolishes the phosphorylation of cdc34 observed in vivo and markedly shifts nuclearly localized cdc34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-110399 |
Ser231 |
FGDDEDDsGTEES |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
The ubiquitin-conjugating enzyme, cdc34, has been implicated in the ubiquitination of a number of vertebrate substrates, including p27(kip1), ikappabalpha, wee1, and myod. We show that mammalian cdc34 is a phosphoprotein that is phosphorylated in proliferating cells. Phosphorylation of cdc34 by the associated kinase maps predominantly to residues 203 and 222. Mutation of cdc34 at ck2-targeted residues, ser-203, ser-222, ser-231, thr-233, and ser-236, abolishes the phosphorylation of cdc34 observed in vivo and markedly shifts nuclearly localized cdc34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-110403 |
Ser236 |
DDSGTEEs |
Homo sapiens |
|
pmid |
sentence |
11546811 |
The ubiquitin-conjugating enzyme, cdc34, has been implicated in the ubiquitination of a number of vertebrate substrates, including p27(kip1), ikappabalpha, wee1, and myod. We show that mammalian cdc34 is a phosphoprotein that is phosphorylated in proliferating cells. Phosphorylation of cdc34 by the associated kinase maps predominantly to residues 203 and 222. Mutation of cdc34 at ck2-targeted residues, ser-203, ser-222, ser-231, thr-233, and ser-236, abolishes the phosphorylation of cdc34 observed in vivo and markedly shifts nuclearly localized cdc34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-110407 |
Thr233 |
DDEDDSGtEES |
Homo sapiens |
|
pmid |
sentence |
11546811 |
The ubiquitin-conjugating enzyme, cdc34, has been implicated in the ubiquitination of a number of vertebrate substrates, including p27(kip1), ikappabalpha, wee1, and myod. We show that mammalian cdc34 is a phosphoprotein that is phosphorylated in proliferating cells. Phosphorylation of cdc34 by the associated kinase maps predominantly to residues 203 and 222. Mutation of cdc34 at ck2-targeted residues, ser-203, ser-222, ser-231, thr-233, and ser-236, abolishes the phosphorylation of cdc34 observed in vivo and markedly shifts nuclearly localized cdc34 to the cytoplasm. |
|
Publications: |
5 |
Organism: |
Homo Sapiens |
+ |
CSNK2B |
phosphorylation
|
CDC34 |
0.357 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251057 |
Ser203 |
APAPDEGsDLFYDDY |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
CDC34 is specifically phosphorylated in vitro by recombinant CK2 and HeLa nuclear extract at five sites within the carboxyl-terminal 36 amino acids of CDC34. | Mutation of CDC34 at CK2-targeted residues, Ser-203, Ser-222, Ser-231, Thr-233, and Ser-236, abolishes the phosphorylation of CDC34 observed in vivo and markedly shifts nuclearly localized CDC34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251058 |
Ser222 |
EVEEEADsCFGDDED |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
CDC34 is specifically phosphorylated in vitro by recombinant CK2 and HeLa nuclear extract at five sites within the carboxyl-terminal 36 amino acids of CDC34. | Mutation of CDC34 at CK2-targeted residues, Ser-203, Ser-222, Ser-231, Thr-233, and Ser-236, abolishes the phosphorylation of CDC34 observed in vivo and markedly shifts nuclearly localized CDC34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251059 |
Ser231 |
FGDDEDDsGTEES |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
CDC34 is specifically phosphorylated in vitro by recombinant CK2 and HeLa nuclear extract at five sites within the carboxyl-terminal 36 amino acids of CDC34. | Mutation of CDC34 at CK2-targeted residues, Ser-203, Ser-222, Ser-231, Thr-233, and Ser-236, abolishes the phosphorylation of CDC34 observed in vivo and markedly shifts nuclearly localized CDC34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251060 |
Ser236 |
DDSGTEEs |
Homo sapiens |
|
pmid |
sentence |
12037680 |
CDC34 is specifically phosphorylated in vitro by recombinant CK2 and HeLa nuclear extract at five sites within the carboxyl-terminal 36 amino acids of CDC34. | Mutation of CDC34 at CK2-targeted residues, Ser-203, Ser-222, Ser-231, Thr-233, and Ser-236, abolishes the phosphorylation of CDC34 observed in vivo and markedly shifts nuclearly localized CDC34 to the cytoplasm. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251061 |
Thr233 |
DDEDDSGtEES |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11546811 |
CDC34 is specifically phosphorylated in vitro by recombinant CK2 and HeLa nuclear extract at five sites within the carboxyl-terminal 36 amino acids of CDC34. | Mutation of CDC34 at CK2-targeted residues, Ser-203, Ser-222, Ser-231, Thr-233, and Ser-236, abolishes the phosphorylation of CDC34 observed in vivo and markedly shifts nuclearly localized CDC34 to the cytoplasm. |
|
Publications: |
5 |
Organism: |
Homo Sapiens |
+ |
RNF7 | down-regulates activity
polyubiquitination
|
CDC34 |
0.736 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271443 |
|
|
Homo sapiens |
|
pmid |
sentence |
10851089 |
SAG was found to be the second family member of Rbx (RING box protein) or ROC (Regulator of cullins) or Hrt that is a component of SCF E3 ubiquitin ligase. Indeed, like ROC1/Rbx1/Hrt1, SAG binds to Cul1 and SAG-Cul1 complex has ubiquitin ligase activity to promote poly-ubiquitination of E2/Cdc34. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |