Summary

Name SMARCA2
Full Name Probable global transcription activator SNF2L2
Synonyms ATP-dependent helicase SMARCA2, BRG1-associated factor 190B, BAF190B, Protein brahma homolog, hBRM, SNF2-alpha, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 | BAF190B, BRM, SNF2A, SNF2L2
Primary ID P51531
Links - -
Type protein
Relations 10
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ SMARCA2form complex img/form-complex.png binding Neural progenitor-specific SWI/SNF 0.817
Publications: 1 Organism: Homo Sapiens
+ SMARCA2form complex img/form-complex.png binding CERF 0.395
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ SMARCA2form complex img/form-complex.png binding SWI/SNF ACTL6A-ARID1A-SMARCA2 variant 0.829
Publications: 1 Organism: Homo Sapiens
+ SMARCA2up-regulates img/direct-activation.png binding SMARCC1 0.908
Publications: 1 Organism: Homo Sapiens
+ SMARCA2form complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA2 variant 0.804
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ SMARCA2form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1B variant 0.825
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMARCA2up-regulates img/direct-activation.png binding SMARCC2 0.897
Publications: 1 Organism: Homo Sapiens
+ SMARCA2form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1A variant 0.821
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMARCA2form complex img/form-complex.png binding GBAF 0.639
Publications: 1 Organism: Homo Sapiens
+ SMARCB1up-regulates activity img/direct-activation.png binding SMARCA2 0.921
Publications: 1 Organism: Homo Sapiens