3.0
Summary
| Name |  LIMK1View Modifications |
| Full Name | LIM domain kinase 1 |
| Synonyms | LIMK-1 | LIMK |
| Primary ID | P53667 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Inhibitors | dabrafenib |
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LIMK1 | down-regulates activity 
phosphorylation
|
CFL2 | 0.691 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LIMK1 | down-regulates
phosphorylation
|
CFL1 | 0.807 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AURKA | up-regulates activity 
phosphorylation
|
LIMK1 | 0.265 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAPKAPK2 | up-regulates
phosphorylation
|
LIMK1 | 0.367 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC42BPA | up-regulates activity
phosphorylation
|
LIMK1 | 0.413 |
| Publications: | 1 | |||
| + | ROCK1 | up-regulates activity
phosphorylation
|
LIMK1 | 0.6 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAK1 | up-regulates activity
phosphorylation
|
LIMK1 | 0.597 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPRG | down-regulates activity
dephosphorylation
|
LIMK1 | 0.263 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LIMK1 | up-regulates activity
phosphorylation
|
AURKA | 0.265 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SSH1 | down-regulates activity
dephosphorylation
|
LIMK1 | 0.616 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | dabrafenib | down-regulates activity
chemical inhibition
|
LIMK1 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RNF6 | down-regulates quantity by destabilization
polyubiquitination
|
LIMK1 | 0.443 |
| Publications: | 1 | Organism: | Homo Sapiens | |