Summary

Name EPHA5
Full Name Ephrin type-A receptor 5
Synonyms Brain-specific kinase, EPH homology kinase 1, EHK-1, EPH-like kinase 7, EK7, hEK7 | BSK, EHK1, HEK7, TYRO4
Primary ID P54756
Links - -
Type protein
Relations 5
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHA5 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.96
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.93
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.95
Publications: 1 Organism: Homo Sapiens