3.0
Summary
| Name |  SIK1View Modifications |
| Full Name | Serine/threonine-protein kinase SIK1 |
| Synonyms | Salt-inducible kinase 1, SIK-1, Serine/threonine-protein kinase SNF1-like kinase 1, Serine/threonine-protein kinase SNF1LK | SIK, SNF1LK |
| Primary ID | P57059 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Inhibitors | dabrafenib |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SIK1 | down-regulates 
phosphorylation
|
CRTC3 | 0.429 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIK1 | down-regulates
phosphorylation
|
CRTC1 | 0.509 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIK1 | down-regulates
phosphorylation
|
CRTC2 | 0.63 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIK1 | down-regulates activity
phosphorylation
|
CRTC2 | 0.63 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | STK11 | up-regulates 
phosphorylation
|
SIK1 | 0.566 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK11 | up-regulates activity
phosphorylation
|
SIK1 | 0.566 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | dabrafenib | down-regulates activity
chemical inhibition
|
SIK1 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |