| + |
AURKA | up-regulates activity 
phosphorylation
|
SOX8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273548 |
Ser327 |
SAPSASAsPTETGPP |
Homo sapiens |
Immature Ovarian Follicle |
| pmid |
sentence |
| 32550913 |
We showed for the first time that Aurora-A interacts directly with SOX8 and phosphorylates the protein at Ser327 to further regulate the SOX8/FOXK1 axis, which modulates cell senescence and glycolysis, ultimately leading to cisplatin resistance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX8 | up-regulates quantity by expression
transcriptional regulation
|
FOXK2 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273613 |
|
|
Homo sapiens |
Immature Ovarian Follicle |
| pmid |
sentence |
| 32550913 |
We showed for the first time that Aurora-A interacts directly with SOX8 and phosphorylates the protein at Ser327 to further regulate the SOX8/FOXK1 axis, which modulates cell senescence and glycolysis, ultimately leading to cisplatin resistance.. Our results showed that SOX8 targets FOXK1, thereby regulating its transcription, which has significant impacts on senescence, glycolysis and chemoresistance in ovarian cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOX8
- 
- 