Summary

Name SESN3
Full Name Sestrin-3
Synonyms SESN3_HUMAN | SEST3
Primary ID P58005
Links - -
Type protein
Relations 1
Function May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding GATOR2 0.446
Publications: 1 Organism: Mus Musculus