Relation Results

Summary

Name TIRAP
Full Name Toll/interleukin-1 receptor domain-containing adapter protein
Synonyms TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2 | MAL
Primary ID P58753
Links - -
Type protein
Relations 8
Pathways EBV infection, Innate Immune Response, Toll like receptors
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B ...
View More

Viewer

Type: Score: Layout: SPV 
0.7750.720.6250.20.4480.392TLR4TIRAPTLR2MYD88TLRsTLR9RNF216

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ TLR4up-regulates activity img/direct-activation.png binding TIRAP 0.775
Identifier Residue Sequence Organism Cell Line
SIGNOR-252064 Homo sapiens HEK-293 Cell
pmid sentence
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2.
Publications: 1 Organism: Homo Sapiens
+ TLR2up-regulates activity img/direct-activation.png binding TIRAP 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-266745 Mus musculus
pmid sentence
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ TIRAPup-regulates activity img/direct-activation.png binding MYD88 0.625
Identifier Residue Sequence Organism Cell Line
SIGNOR-252063 Homo sapiens
pmid sentence
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-110215 Homo sapiens
pmid sentence
Stimulation of Toll-like receptor (TLR) 4 leads to the activation of both MyD88-dependent and MyD88-independent pathways through the recruitment of adaptors TIRAP/MyD88 and TRIF/TRAM, respectively.
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection, Innate Immune Response, Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding TIRAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-216298 Homo sapiens
pmid sentence
These differences are explained by the discovery of TIR domain’containing adaptor molecules, including MyD88, TIRAP (Mal), TRIF and TRAM, which are recruited by distinct TLRs and activate distinct signaling pathways
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, Toll like receptors
+ TLR9up-regulates activity img/direct-activation.png binding TIRAP 0.448
Identifier Residue Sequence Organism Cell Line
SIGNOR-266748 Mus musculus
pmid sentence
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ TLR4up-regulates img/direct-activation.png binding TIRAP 0.775
Identifier Residue Sequence Organism Cell Line
SIGNOR-110337 Homo sapiens
pmid sentence
Mal (myd88-adapter-like) is required for toll-like receptor-4 signal transduction.
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TIRAP 0.392
Identifier Residue Sequence Organism Cell Line
SIGNOR-271607 Homo sapiens HEK-293 Cell
pmid sentence
Triad3A promotes proteolytic degradation of adapter proteins. A, Triad3A promotes down-regulation of TIRAP, TRIF, and RIP1 proteins.
Publications: 1 Organism: Homo Sapiens
a simple tooltip