3.0
Summary
| Name |  PSME3View Modifications |
| Full Name | Proteasome activator complex subunit 3 |
| Synonyms | 11S regulator complex subunit gamma, REG-gamma, Activator of multicatalytic protease subunit 3, Ki nuclear autoantigen, Proteasome activator 28 subunit gamma, PA28g, PA28gamma | |
| Primary ID | P61289 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK2 | up-regulates activity 
phosphorylation
|
PSME3 | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PSME3 | up-regulates activity
binding
|
26S Proteasome | 0.628 |
| Publications: | 1 | |||
| + | PSME3 | down-regulates quantity by destabilization 
binding
|
SIRT7 | 0.2 |
| Publications: | 1 | |||