| + |
ATAT1 | up-regulates quantity by stabilization 
acetylation
|
TUBA1B |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272245 |
Lys40 |
DGQMPSDkTIGGGDD |
in vitro |
|
| pmid |
sentence |
| 29703898 |
Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit has been identified as an important conserved site of microtubule acetylation (6–8). This modification is considered a hallmark of stable, long-lived microtubules |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SETD2 | up-regulates activity
methylation
|
TUBA1B |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269090 |
Lys40 |
DGQMPSDkTIGGGDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27518565 |
The histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates α-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMA1 | up-regulates
binding
|
TUBA1B |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11956313 |
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Elongator complex | up-regulates activity
acetylation
|
TUBA1B |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269719 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
Elongator Subunits Interact with the Microtubules and Are Required for Proper Acetylation of α-Tubulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTL | down-regulates 
tyrosination
|
TUBA1B |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22020298 |
Tubulin tyrosine ligase (ttl) adds a c-terminal tyr to __tubulin as part of a tyrosination/detyrosination cycle present in most eukaryotic cells. / ttl inhibits spontaneous tubulin polymerization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBA1B | up-regulates 
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269727 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TUBA1B
- 
- 