3.0
Summary
| Name |  PKD1View Modifications |
| Full Name | Polycystin-1 |
| Synonyms | Autosomal dominant polycystic kidney disease 1 protein |
| Primary ID | P98161 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKX | up-regulates 
phosphorylation
|
PKD1 | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKD1 | up-regulates activity
binding
|
SIAH1 | 0.338 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKD1 | down-regulates quantity by destabilization 
binding
|
JADE1 | 0.332 |
| Publications: | 1 | Organism: | Homo Sapiens | |