4.0
Summary
| Name |  DR1
|
| Full Name | Protein Dr1 |
| Synonyms | Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein |
| Primary ID | Q01658 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DR1 | form complex 
binding
|
NC2 complex | 0.747 |
| Publications: | 1 | Organism: | Homo Sapiens | |