3.0
Summary
| Name |  ROR1
|
| Full Name | Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
| Synonyms | Neurotrophic tyrosine kinase, receptor-related 1 | NTRKR1 |
| Primary ID | Q01973 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ROR1 | up-regulates 
phosphorylation
|
SRC | 0.319 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-miR-382-5p | down-regulates quantity by repression 
post transcriptional regulation
|
ROR1 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WNT5A | up-regulates
binding
|
ROR1 | 0.746 |
| Publications: | 3 | Organism: | Homo Sapiens | |