Summary

Name NRG1
Full Name Pro-neuregulin-1, membrane-bound isoform
Synonyms Pro-NRG1 | GGF, HGL, HRGA, NDF, SMDF
Primary ID Q02297
Links - -
Type protein
Relations 6
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding ERBB2 0.783
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB4 0.901
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NRG1 0.368
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding ERBB3 0.867
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding ErbB receptor family 0.903
Publications: 1 Organism: Homo Sapiens