Summary

Name GPS1
Full Name COP9 signalosome complex subunit 1
Synonyms SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1, Protein MFH | COPS1, CSN1
Primary ID Q13098
Links - -
Type protein
Relations 2
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

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Relations

Regulator Mechanism target score ℹ
+ GPS1form complex img/form-complex.png binding COP9 signalosome variant 1 0.919
Publications: 1 Organism: Homo Sapiens
+ GPS1form complex img/form-complex.png binding COP9 signalosome variant 2 0.919
Publications: 1 Organism: Homo Sapiens