| + |
MAPK7 | up-regulates 
phosphorylation
|
MAP2K5 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99127 |
Ser129 |
VNTRAGPsQHSSPAV |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99131 |
Ser137 |
QHSSPAVsDSLPSNS |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99135 |
Ser142 |
AVSDSLPsNSLKKSS |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99139 |
Ser149 |
SNSLKKSsAELKKIL |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
MAP2K5 | up-regulates activity
phosphorylation
|
MAPK7 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259824 |
Thr219 |
AEHQYFMtEYVATRW |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation, is activated selectively by dual phosphorylation in the TEY motif by MAPK kinase 5 (MEK5). ERK5 is activated selectively by dual phosphorylation on Thr218 and Tyr220 in the TEY motif by its only upstream kinase, MEK5, a member of the MEK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259825 |
Tyr221 |
HQYFMTEyVATRWYR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation, is activated selectively by dual phosphorylation in the TEY motif by MAPK kinase 5 (MEK5). ERK5 is activated selectively by dual phosphorylation on Thr218 and Tyr220 in the TEY motif by its only upstream kinase, MEK5, a member of the MEK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255453 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SL-327 | down-regulates 
chemical inhibition
|
MAP2K5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104933 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11160424 |
The mek1/2 inhibitors pd98059, sl327, and u0126 have been extensively used to implicate erk1/2 in neuroplasticity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAP3K2 | up-regulates
phosphorylation
|
MAP2K5 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12912994 |
Mekk2 and mekk3 are mapk kinase kinases that bind, phosphorylate and activate mek5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates
phosphorylation
|
MAP2K5 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12912994 |
Mekk2 and mekk3 are mapk kinase kinases that bind, phosphorylate and activate mek5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GHR | up-regulates activity
phosphorylation
|
MAP2K5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255452 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MAP3K2 | up-regulates 
|
MAP2K5 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84184 |
|
|
Homo sapiens |
HEK-293 Cell, T-lymphocyte |
| pmid |
sentence |
| 11073940 |
Mekk2 activated bmk1/erk5 to a greater extent, which might correlate with a higher affinity mekk2-mek5 interaction. A dominant negative form of mek5 blocked the activation of bmk1/erk5 by mekk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K5 | up-regulates
phosphorylation
|
MAPK7 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12912994 |
Mek5 is the mapk kinase that phosphorylates and activates erk5 in response to growth factors, oxidative stress, and hyperosmotic conditions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
Kato et al. reported that mek5 specifically activates bmk1 but not other mammalian map kinasesin vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide | down-regulates
chemical inhibition
|
MAP2K5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIX-02188 | down-regulates
chemical inhibition
|
MAP2K5 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAP2K5
- 
- 