Summary

Name MTA1
Full Name Metastasis-associated protein MTA1
Synonyms MTA1_HUMAN
Primary ID Q13330
Links - -
Type protein
Relations 14
Function Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SNAI2 0.432
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MBD2/NuRD complex 0.798
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination MTA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SNAI1 0.474
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MTA1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CXCL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MTA3 0.631
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MBD3/NuRD complex 0.808
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MTA1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EPHA2 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CLOCK/BMAL1 0.2
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding MTA1/DJ1 complex 0.333
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding COP1 0.2
Publications: 1 Organism: Homo Sapiens