Summary

Name CACNA1C
Full Name Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2 | CACH2, CACN2, CACNL1A1, CCHL1A1
Primary ID Q13936
Links - -
Type protein
Relations 6
Inhibitors Isradipine
Function Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CACNA1C 0.474
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CACNA1C 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CACNA1C 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png CACNA1C 0.2
Publications: 1 Organism: Homo Sapiens