| + |
NDEL1 | up-regulates activity 
binding
|
DYNC1H1 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252159 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 11163259 |
LIS1 specifically binds the P1 loop domain of CDHC, while NUDEL binds the C-terminal region as well as a distinct binding site in the P1 loop domain. LIS1 and NUDEL regulate CDHC localization and motor function. Reduction of LIS1 leads to mislocalization of NUDEL, CDHC, β-tubulin, and the Golgi complex |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAFAH1B1 | up-regulates activity
binding
|
DYNC1H1 |
0.881 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252158 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 11163259 |
We demonstrate that LIS1 directly interacts with the cytoplasmic dynein heavy chain (CDHC) and NUDEL. LIS1 specifically binds the P1 loop domain of CDHC, while NUDEL binds the C-terminal region as well as a distinct binding site in the P1 loop domain. LIS1 and NUDEL regulate CDHC localization and motor function. Reduction of LIS1 leads to mislocalization of NUDEL, CDHC, β-tubulin, and the Golgi complex |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
INTS4 | up-regulates quantity 
|
DYNC1H1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261186 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23904267 |
We propose a model in which nuclear localized Integrator complex, including ASUN, mediates 3′-end processing of snRNA, which in turn is required for normal processing of mRNA encoding a key regulator(s) of cytoplasmic dynein localization. When Integrator activity is compromised (e.g., by knockdown of an essential subunit), production of critical transcript(s) during interphase is impaired, leading to reduction of perinuclear dynein at G2/M. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DYNC1H1
- 
- 